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T the direct or indirect targets of WhiJ regulation or about the role of the antisigma-like protein (SCO4544). The apparently repressing action of the whiJ locus raises the possibility that some or all of its paralogues may also act as developmental brakes. If so, it may be that during `normal' colony development on laboratory media, these brakes are all off ?in other words, all relevant checkpoin
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Oportion to the number of genome copies in the tip compartment) and eventually splits, part remaining at the tip and part adhering to the lateral wall,Fig. 8. The mre gene cluster is absent from most simple actinobacteria. The reciprocal BLASTP best-hit tabulation includes the region from SCO2605 to SCO2615. The numbered nodes refer to Fig. 2. See Fig. 3 legend and text for further details. The mr
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Oportion to the number of genome copies in the tip compartment) and eventually splits, part remaining at the tip and part adhering to the lateral wall,Fig. 8. The mre gene cluster is absent from most simple actinobacteria. The reciprocal BLASTP best-hit tabulation includes the region from SCO2605 to SCO2615. The numbered nodes refer to Fig. 2. See Fig. 3 legend and text for further details. The mr
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Hat this (partly) reflects differences in the complement of WhiJ-like signal transduction cascades. The strikingly reduced number of paralogues in S. venezuelae (one of several streptomycetes that lack a cluster orthologous to whiJ itself) may underpin the ability of S. venezuelae to sporulate exceptionally readily and comprehensively even in submerged culture, which has led to its adoption as a m
1
Hat this (partly) reflects differences in the complement of WhiJ-like signal transduction cascades. The strikingly reduced number of paralogues in S. venezuelae (one of several streptomycetes that lack a cluster orthologous to whiJ itself) may underpin the ability of S. venezuelae to sporulate exceptionally readily and comprehensively even in submerged culture, which has led to its adoption as a m
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Tively long-established clusters. Twelve other S. coelicolor whiJ-like genes were represented in around half of streptomycetes (SCO2381*, 2865, 2869*, 3365*, 4176, 4301, 4678, 4998, 6129, 6537, 6629*, 7579) [asterisks indicate occurrence also in some other complex actinomycete(s)]; while seven others were found in four or fewer streptomycetes (SCO0704, 2246, 2253, 4543, 5125,Fig. 7. Phylogenetic a
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Hat this (partly) reflects differences in the complement of WhiJ-like signal transduction cascades. The strikingly reduced number of paralogues in S. venezuelae (one of several streptomycetes that lack a cluster orthologous to whiJ itself) may underpin the ability of S. venezuelae to sporulate exceptionally readily and comprehensively even in submerged culture, which has led to its adoption as a m
1
Hat this (partly) reflects differences in the complement of WhiJ-like signal transduction cascades. The strikingly reduced number of paralogues in S. venezuelae (one of several streptomycetes that lack a cluster orthologous to whiJ itself) may underpin the ability of S. venezuelae to sporulate exceptionally readily and comprehensively even in submerged culture, which has led to its adoption as a m